Wind-Up Animation:

Description: A wind-up animation usually accompanies a strong single-hit attack. You’ll often see the boss or elite monster prepare by gathering energy, such as raising their weapon, charging a spell, or focusing their power in a particular area. This animation can last for a moment, giving you the opportunity to Path of exile currency react.
What to Do: As soon as the wind-up starts, position yourself away from the enemy and avoid standing still. You may need to dodge the attack by moving toward an open area or behind cover. Flicker Strike is perfect for repositioning instantly, while Dash works well for escaping AoE bursts.
Vibration or Charge Sound:

Description: Some enemies will emit a low-frequency vibration or specific sound as they prepare for a heavy single-hit attack. These sound cues can often be heard just before the glowing effects or charge-up begins, providing an additional warning.
What to Do: Pay close attention to audio cues, especially in fast-paced fights. As soon as you hear the charge sound or vibration, start moving away from the area where the attack will land. If you have mobility skills with a cooldown, ensure they are ready for this moment.
How to React:
Movement and Positioning:

Move Early: Once you see the telegraphed cue (glow, aura, charge, or animation), reposition yourself immediately. These single-hit attacks are often very telegraphed, meaning there is plenty of time to move out of the area before they strike. Avoid standing near the enemy and try to get to the edges of the arena or behind cover to block the attack.
Use Movement Skills: Abilities like Flicker Strike, Dash, or Leap Slam will help you move quickly and avoid damage. If the boss is charging up a single-hit attack, use your mobility skills to Path of exile currency for sale get out of the line of fire. In particular, Flicker Strike can teleport you a short distance, allowing you to avoid devastating hits.